Pharmacogenomic data for the following specific variants are reviewed and reported (if present): Each sample is tested for specific variations with known functional impact. This panel provides a comprehensive analysis for multiple genes that have strong pharmacogenomic associations with medications used in the treatment of psychiatric disorders, including depression. Specimen Stability Information : Frozen (preferred) 1 year/Ambient/Refrigerated Provide concentration of DNA and volume on tube. The preferred volume is 100 mcL at a concentration of 50 ng/mcL.Ģ. Specimen Stability Information: Ambient 30 daysġ. Specimen Volume: 2 Swabs, use 2 kits for collectionĬollection Instructions: Collect and send specimen per kit instructions.Īdditional Information: Due to lower concentration of DNA yielded from saliva, testing cannot proceed to reflex testing for CYP2D6 sequencing and will stop after initial testing is complete. Supplies: Saliva Swab Collection Kit (T786) Patient Preparation: Patient should not eat, drink, smoke, or chew gum 30 minutes prior to collection. Specimen Stability Information: Ambient (preferred) 9 days/Refrigerated 30 days Send whole blood specimen in original tube. ![]() Submit only 1 of the following specimens:Ģ. Submit the required form with the specimen. Prior Authorization is available for this test. Prior Authorization is available for this assay. Approximately 3% of samples require tier 2 testing. Tier 2 testing involves sequencing using fluorescent dye-terminator chemistry and is only done if an ambiguous phenotype results from tier 1 testing. ![]() Unitary and tandem CYP2D7-2D6 ( *13) alleles and CYP2D6-2D7 (eg, *4N, *36, and *68) alleles can also be detected. Duplications and multiplications of alleles are also identified. All samples also have copy number determined by PCR-based 5'-nuclease assay. ![]() Tier 1 uses a polymerase chain reaction (PCR)-based 5'-nuclease assay to determine the variants present. This test includes targeted testing to evaluate the following genes: ANKK1, ADRA2, CHRNA3, COMT, CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, DRD2, EPHX1, GRIK4, HLA-A*31:01, HLA-B*15:02, HTR2A, HTR2C, MTHFR, OPRM1, SCN1A, SLC6A4 (5-HTT), UGT2B15.ĬYP2D6 testing is done in 2 tiers when needed.
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